Loss of mTOR signaling affects cone function, cone structure and expression of cone specific proteins without affecting cone survival
نویسندگان
چکیده
منابع مشابه
Loss of mTOR signaling affects cone function, cone structure and expression of cone specific proteins without affecting cone survival.
Cones are the primary photoreceptor (PR) cells responsible for vision in humans. They are metabolically highly active requiring phosphoinositide 3-kinase (PI3K) activity for long-term survival. One of the downstream targets of PI3K is the kinase mammalian target of rapamycin (mTOR), which is a key regulator of cell metabolism and growth, integrating nutrient availability and growth factor signa...
متن کاملCone and rod function in cone degenerations
Progressive cone dystrophy (CD) is usually marked in the initial stages by reduced visual acuity, color vision deficiency and alterations in the photopic electroretinogram, while morphological alterations can be very mild; in some forms rods are affected in a later stage as well. We examined 40 patients with progressive cone dystrophy to determine the extent of functional losses in the cone sys...
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(a) (b) Figure 8: The nal set of directions from that covers G S in thick gray lines. Two views are provided with (a) presents the regular view of Figures 5 to 7 and (b) shows the entire Gauss map. See also Figure 1. (a) (b) Figure 6: The boundary and central silhouettes of G S in thick dark gray lines is projected onto the plane z = 1 in thick light gray lines, in (a). In (b), The convex hull ...
متن کاملStructure of cone photoreceptors.
Although outnumbered more than 20:1 by rod photoreceptors, cone cells in the human retina mediate daylight vision and are critical for visual acuity and color discrimination. A variety of human diseases are characterized by a progressive loss of cone photoreceptors but the low abundance of cones and the absence of a macula in non-primate mammalian retinas have made it difficult to investigate c...
متن کاملLocal cone and rod system function in progressive cone dystrophy.
PURPOSE To compare the patterns of local cone and rod system impairment in patients with progressive cone dystrophy (CD) using psychophysical and electrophysiological techniques. METHODS Local cone system function was assessed by measuring cone system thresholds (visual fields) and cone-mediated multifocal electroretinograms (mfERGs). Rod system function was assessed by measuring rod system t...
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ژورنال
عنوان ژورنال: Experimental Eye Research
سال: 2015
ISSN: 0014-4835
DOI: 10.1016/j.exer.2015.04.006